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were recorded. Laboratory data were collected at the time of onset of MAS (clinically determined), and thereafter as clinically

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and lymphadenopathy were common clinical features. Platelet counts fell dramatically, from an average of 346 to 99 109/l. Mean erythrocyte sedimentation rate (in three patients) fell from 115 to 28 mm/h. Eight had abnormal liver function during

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one antithymocyte globulin. Two of three patients with significant renal impairment

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